Oncogene addiction: resetting the safety switch?

Oncogene addiction: resetting the safety switch?

The term " oncogene addiction " was first coined by Dr. Bernard Weinstein to describe the exquisite dependency of tumor cells on the expression of specific oncogenes for their relentless proliferation and survival [1]. Since cancers generally have accumulated multiple genetic and epigenetic abnormalities, it is surprising that they can remain dependent on any particular oncogenic driver. This "...

Oncogene addiction

to begin with and be bloody-minded about continuing this specific interest. You should always enjoy biology, even when some aspects of doing research are tedious or even unsuccessful. If you don’t enjoy what you are doing, then you might as well be in business and be paid well to do boring things! Beyond that it is a matter of personal style; my advice depends upon where you are on the personal...

Targeting of non-oncogene addiction

pathways control all phases of tumor development and are critical in cancer therapy as they are largely responsible for the ability of tumor cells to survive or die in response to chemotherapy and radiotherapy. The p38 MAPK signaling pathway is one of the routes that cells use extensively to interpret extracellular signals and orchestrate appropriate responses. This pathway was originally chara...

Tumor dormancy and oncogene addiction.

Cancer is caused by genetic changes that activate oncogenes or inactivate tumor suppressor genes. The repair or inactivation of mutant genes may be effective in the treatment of cancer. Indeed, drugs that target oncogenes can be effective in the treatment of cancer. However, it is still unclear why the inactivation of a single cancer-associated gene would ever result in the elimination of tumor...

Oncogene Addiction in Solid Tumors